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KMID : 0356919950290040501
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Korean Journal of Anesthesiology
1995 Volume.29 No. 4 p.501 ~ p.505
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Neuromuscular and Cardiovascular Effects of Rocuronium during Propofol, Fentanyl, N2O/O2, Isoflurane Anesthesia
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김성열
이정석/이주철/김순임/황경호/김선종/박욱
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Abstract
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The neuromuscular blocking and cardiovascular effects of rocuronium (Roc) have been compared with succinylcholine (Scc), mivacurium (Miv) and vecuronium (Vec). Thirty six healthy adult patients were randomly assigned to receive Roc (0.6 mg/kg),
Scc
(1.0
mg/kg), Miv (0.16 mg/kg) and Vec (0.08 mg/kg) during induction with propofo1 and fentanyl. The 3M surface electrodes (Red Dot, Ag/Agc1) were applied over the ulnar nerve at the wrist and supramaximal transcutaneous stimulation from a peripheral
nerve
stimulator (Innervator, Fisher & Paykel, New Zealand) using a 0.2 ms square wave pulses in duration at 0.1 Hz were applied. The twitch response of the thumb adductor was measured mechanomyographically using 2 kg load cell strain gauge (Model No.
505H,
RS Component, Ltd, U.K.) with a thumb piece modification. Recordings were made on a Gould TA 240 Easy Graf Thermal array Recorder with a 6600 series transducer signal. The time from injection of muscle relaxant to complete depression of control
twitch
height onset), the time from injection to 23% recovery of control twitch height (clinical duration, CD) and recovery indices (RI, time from 25% to 75% recovery of control twitch height) were measured, and the cardiovascular effects; heart rate
(HR)
and
mean arterial pressure (MAP), were determined before and after injection of muscle relaxants. Onset times for patients, receiving Roc, Scc, Vec and Miv were 65.0±13.5 s, 54.0±5.2 s, 191.0±58.0 s and 201.3±37.6 s. CDs were 33.6±6.6 min,
8.4±2.1
min, 21.6±4.8min and 13.0±2.2 min. Ris were 12.9±4.3 min, 5.5±1.2 min, 10.9±3.8 min and 6.9±1.3 min. There were no significant changes of HR, however MAP were decreased significantly from a min after injection of Roc. Consequently, onset
time
of
Roc were faster than that of Miv or vec and slower than that of Scc but not significant. However, CD and RI of Roc were significantly longer than those of the others, with minimum cardiovascular effects. (Korean J Anesthesiol 1995; 29: 501∼505)
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KEYWORD
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